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Life sciences · Phase 2 Trial
ClinicalTrials.gov · October 29, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Phase 2 Trial.
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Registry record from ClinicalTrials.gov (NCT07693608). This is a study registration, not published results. Lead sponsor: University of Texas Southwestern Medical Center. Recruitment status: ACTIVE_NOT_RECRUITING. Phase: PHASE2. Study type: INTERVENTIONAL. Enrollment: 45 participants (ESTIMATED). Conditions: Obesity, Methamphetamine Use Disorder, Cocaine Use Disorder, Stimulant Use Disorders. Interventions: DRUG: Tirzepatide. Primary outcome measures: Effect of tirzepatide on self-reported use of stimulants , 32 weeks. Brief summary: This open label pilot study will assess the feasibility and preliminary efficacy of tirzepatide which will be prescribed under its FDA approved weight management indication in adults with moderate or severe methamphetamine, cocaine or prescription stimulant use disorder (MUD) who also meet criteria for obesity or overweight with comorbidities. Up to 30 participants will receive 20 weeks of once weekly tirzepatide, followed by an observational follow up period. The study also incorporates MRI at seven time points to explore neural biomarkers associated with treatment response. All participants will receive 12 weeks of contingency management (CM) combined with cognitive behavioral therapy (CBT). Together, these pharmacologic, neuroimaging, and behavioral components will evaluate tirzepatide's potential to improve health and substance use outcomes in individuals with MUD.