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Life sciences · Interventional Study
ClinicalTrials.gov · November 9, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07924657). This is a study registration, not published results. Lead sponsor: Xuanwu Hospital, Beijing. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 40 participants (ESTIMATED). Conditions: Alzheimer s Disease. Interventions: OTHER: Acoustic Stimulation. Primary outcome measures: Computerized 1 × 5 Random Sequence Learning Task Accuracy , Before sleep (baseline), the morning after sleep, and 1 week after the initial assessment.; Computerized 1 × 5 Random Sequence Learning Task Reaction Time , Before sleep (baseline), the morning after sleep, and 1 week after the initial assessment.. Brief summary: This summary focuses on the acoustic stimulation part of the study. The goal of this interventional study is to learn if acoustic stimulation during sleep works to improve cognitive function in patients with Alzheimer's disease. It will also learn about safety and feasibility. The main questions are: Does acoustic stimulation during NREM sleep improve cognitive function in patients with mild cognitive impairment due to Alzheimer's disease (AD-MCI)? How does acoustic stimulation compare with sham stimulation? Researchers will compare acoustic stimulation with sham stimulation. Participants will: Be assigned to the acoustic stimulation group (n=20) or the sham stimulation group (n=20). Receive a familiar, comfortable sound at the bedside during stable NREM sleep, or sham stimulation, with 30 seconds of stimulation every 1 minute, triggered upon entering NREM sleep, with no limit on the number of stimulations. Complete cognitive assessments and sleep EEG monitoring before and after the intervention. Be monitored for safety throughout the study. The study is sponsored by Xuanwu Hospital, Capital Medical University. It is funded by the National Natural Science Foundation of China Key International Cooperation Project (Grant No. 82220108009). The study period runs from ethics approval to December 2024. No other centers are participating. Participants will be 60-75 years old and recruited from the neurology wards of Xuanwu Hospital.