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Life sciences · Preprint
arXiv · October 22, 2026
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Diffusion models have become strong priors for solving inverse problems. However, nonlinear inverse problems such as phase retrieval remain challenging when multiple measurement-consistent solutions are distinguishable only by the prior; we call such measurements ambiguous. Existing diffusion-based samplers rely on local approximations during reconstruction. For an ambiguous measurement, these approximations can allow measurement guidance to favor a measurement-consistent mode that is close to a prior-supported mode but is itself not supported by the prior. Evaluation often masks this type of failure by reporting the best-of-$k$ runs, where the best is selected by comparison to the ground truth. We introduce Prior-Consistent DAPS (PC-DAPS), a variant of Decoupled Annealing Posterior Sampling (DAPS) designed to address this failure case by maintaining multiple candidate solutions within a single sampling run. As annealing noise decreases, PC-DAPS prunes and replaces weaker candidates according to their prior consistency, without any ground-truth access. PC-DAPS reduces the incidence of prior-inconsistent samples and improves sample quality on nonlinear inverse problems while preserving sample quality and diversity on linear inverse problems.