Loading
Life sciences · Journal article
Internet Interventions · September 3, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Journal article.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Internet-based interventions for perinatal depression reduce depressive symptoms in new and expectant mothers. However, modifiers of their effects, and prognostic factors of adherence, are unknown. To assess modifiers of effectiveness and deterioration, and prognostic factors of adherence in internet-based interventions for perinatal depression. Systematic searches were conducted in three bibliographic databases on February 7, 2025. Two independent researchers identified randomized controlled trials (RCTs) of internet-based interventions for perinatal depression. We conducted conventional and two-stage individual participant data meta-analysis (IPDMA). Eighteen studies were eligible, and data from nine (n = 1094 participants) were pooled in IPDMA. We found evidence of a difference in post-treatment depressive symptoms between participants in the internet-based intervention and controls (SMD = 0.29 [95%CI: 0.03-0.54], small effect size), increase in response (RR = 1.97 [95%CI: 1.57-2.47]) and remission (RR = 1.73 [95%CI: 1.38-2.18]). The interventions were effective for anxiety symptoms (SMD = 0.26 [95%CI: 0.11-0.40]) but not for reliable deterioration (OR = 0.80 [95%CI: 0.49-1.32]). No modifiers of effectiveness or deterioration, or prognostic factors of adherence were identified. Baseline depressive symptoms and comorbid anxiety were prognostic factors for higher depressive symptoms at post-treatment. Internet-based interventions for perinatal depression are effective for depressive and anxiety symptoms in new and expectant mothers. They may be offered to patients regardless of their age, education, relationship status, employment, baseline depressive or anxiety symptoms, previous treatment, number of children, or ethnic minority status, if they wish to follow them. RCTs should collect more information on factors relevant to the perinatal period, such as partner's mental health and pregnancy complications. Open Science Framework (https://osf.io/98tms).