Loading
Treatment of Major Depression / Bipolar Disorder and Treatment · Journal article
Early Intervention in Psychiatry · July 27, 2026
Early or partial results. Treat as a signal, not a conclusion.
This single-centre study of 94 FEP patients found that structured diagnostic interviews (SCID-I) detected comorbid depression and anxiety disorders substantially more often than clinical documentation recorded them over a 1-year follow-up period. The findings suggest systematic underdiagnosis of mood and anxiety comorbidities in routine FEP care, but the observational design and retrospective extraction of clinical diagnoses do not establish whether this represents true missed diagnosis, documentation failure, or clinician disagreement with research criteria.
Cross-sectional observational study with retrospective clinical record review. Patients with first-episode psychosis (nonaffective or affective) admitted to the clinical psychiatric services of Turku Psychiatry during a 5-year period. Screened from 3772 consecutive admissions; 94 met final inclusion criteria.. Intervention: Structured diagnostic interview (SCID-I) for research diagnoses.. Compared with: Clinical diagnoses (ICD-10) documented in patient records at 1 year from admission.. n = 94. Turku Psychiatry clinical services, Finland; single centre..
42% (n=28) of nonaffective FEP patients met SCID-I criteria for lifetime major depression; only half received depression diagnosis (F32/F33) in clinical records during 1-year follow-up 9% (n=6) of nonaffective FEP patients met SCID-I criteria for current major depression 45% (n=42) of the whole FEP sample had lifetime anxiety disorders by SCID-I; 48% (n=45) had current anxiety disorders
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
Clinicians should be aware that structured diagnostic assessment may identify mood and anxiety comorbidities in FEP patients more frequently than routine clinical documentation captures them. Implementation of systematic screening and diagnostic procedures at first-episode services may improve recognition and enable better individualised treatment planning.
Single-centre observational study with modest sample size comparing research diagnoses to clinical records; identifies an underrecognition gap but lacks intervention, control group, or prospective validation of the diagnostic discrepancy.
As stated by the source record.
Quoted from the source exactly as published.
Clinicians should be aware that structured diagnostic assessment may identify mood and anxiety comorbidities in FEP patients more frequently than routine clinical documentation captures them. Implementation of systematic screening and diagnostic procedures at first-episode services may improve recognition and enable better individualised treatment planning.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
BACKGROUND: Clinically significant depression and anxiety disorders are common in different phases of first-episode psychosis (FEP). These comorbidities can be undervalued in clinical practice. We studied how often comorbid depression and anxiety disorders are diagnosed using the SCID-I interview in FEP patients and explored the corresponding clinical diagnoses for the same sample. METHOD: As a part of the Turku Early Psychosis Study (TEPS), we screened 3772 consecutive admissions during 5 years to the clinical psychiatric services of Turku Psychiatry. The final FEP sample in this study consisted of 94 patients with nonaffective (n = 67) and affective (n = 27) psychoses. Research diagnoses (SCID-I) were compared with clinical diagnoses (ICD-10) obtained from patient records 1 year from admission. RESULTS: SCID-I indicated that 42% (n = 28) and 9% (n = 6) of nonaffective FEP patients fulfilled the diagnostic criteria for lifetime (LT) and current (C) major depression. Depression diagnosis (F32 or F33) was recorded in only half of these cases in clinical practice during the 1-year follow-up. The SCID-I also indicated that 45% (n = 42) and 48% (n = 45) of the whole FEP sample had LT and C anxiety disorders according to the SCID-I. An anxiety disorder diagnosis (F40-48) was recorded for only 40% of the patients with SCID-based LT or C anxiety disorder in clinical practice during the 1-year follow-up period. CONCLUSION: Comorbid depression and anxiety disorders are common in FEP patients but are often not clinically diagnosed. A systematic diagnostic procedure in clinical practice will characterise the full syndromic nature of FEP for personalised treatment strategy.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.