Loading
Life sciences · Journal article
Biology Direct · October 9, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Journal article.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Promoting the recruitment and function of human brown adipose tissue (BAT) holds significant promise for preventing and treating obesity and related metabolic complications. While identifying genes to enhance BAT recruitment and thermogenic activation is crucial, traditional upregulation methods are often inefficient. Small molecules, however, can facilitate this process through safe, rapid mechanisms. In our study, we employed the Drug Enhanced Cell Conversion using Differential Expression (DECCODE) method, an unbiased drug-induced transcriptomics approach, to identify small molecules that facilitate cell conversion. We began by establishing a transcriptomic profile of human pluripotent stem cell (PSC)-derived BAT cells as our target, then assessed small molecules from the Library of Integrated Network-based Cellular Signatures (LINCS) collection for similarity to this target, identifying a candidate pool. Experimental validation in human thermogenic adipocytes showed that two drugs already approved for other indications, Saxagliptin and Tolvaptan, significantly enhance thermogenic activation. Our approach offers a practical, resource-efficient way to identify small molecules with repurposing potential. While thorough experimental validation remains essential, this in silico framework is versatile and could be broadly applied across various cellular lineages.