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Bipolar Disorder / PET / Post Traumatic Stress Disorder · Observational Study
ClinicalTrials.gov · August 7, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a completed observational study registration examining glutamate system involvement in depression, post-traumatic stress disorder, and bipolar disorder using MRI and PET imaging. No results are posted in this registry record; the entry describes study design and procedures only, without outcome data or findings to evaluate clinical or scientific significance.
Observational. Major Depressive Disorder, Post-Traumatic Stress Disorder, Bipolar Disorder; age from 18 Years; to 70 Years; accepts healthy volunteers. Intervention: Cognitive Testing; Magnetic Resonance Imaging; Positron Emission Tomography. n = 180. 1 site: United States.
This is a completed observational study registration examining glutamate system involvement in depression, post-traumatic stress disorder, and bipolar disorder using MRI and PET imaging. No results are posted in this registry record; the entry describes study design and procedures only, without outcome data or findings to evaluate clinical or scientific significance.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
No clinical impact can be assessed from this registry record, as results are not reported. Clinicians and researchers should await publication of findings to determine whether glutamate system abnormalities are confirmed in these psychiatric populations and whether such findings inform treatment.
This is a completed observational registry record with no reported results; it describes study design and procedures only, without outcome data to evaluate.
As stated by the source record.
Quoted from the source exactly as published.
No clinical impact can be assessed from this registry record, as results are not reported. Clinicians and researchers should await publication of findings to determine whether glutamate system abnormalities are confirmed in these psychiatric populations and whether such findings inform treatment.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT02727972). This is a study registration, not published results. Lead sponsor: Yale University. Recruitment status: COMPLETED. Study type: OBSERVATIONAL. Enrollment: 180 participants (ESTIMATED). Conditions: Major Depressive Disorder, Post-Traumatic Stress Disorder, Bipolar Disorder. Interventions: BEHAVIORAL: Cognitive Testing; OTHER: MRI; RADIATION: PET. Primary outcome measures: Evidence of glutamate availability (mGluR5) in psychiatric disorders confirmed by MRI and PET data. , Through study completion date, an average of 4 years.. Brief summary: This research study is designed to look at the involvement of the glutamate system in depression. Each subject will undergo a screening appointment to determine study eligibility. Thereafter, the study will take 2 or 3 visits depending on schedule availability and will consist of one MRI scan, and PET scan. Subjects will also participate in cognitive testing. Depending on camera time, staff availability and subject schedule, total study participation may last 1-2 months.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.