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Bacteremia / Drug Resistance / Bacterial · Observational Study
ClinicalTrials.gov · August 14, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a registry record for a planned retrospective observational study examining antibiotic de-escalation and antimicrobial resistance in four Thai hospitals using historical data from 2019–2024. No results are posted; the record documents study design and scope only.
Observational. Drug Resistance, Bacterial, Bacteremia. Intervention: No antibiotic de-escalation; De-escalation by using Access or Low Watch parenteral antib…; De-escalation by cessation of parenteral antibiotics. Compared with: No antibiotic de-escalation after short-course parenteral antibiotics. n = 108,000. 4 sites: Thailand.
This is a registry record for a planned retrospective observational study examining antibiotic de-escalation and antimicrobial resistance in four Thai hospitals using historical data from 2019–2024. No results are posted; the record documents study design and scope only.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
This is a clinical trial registry record describing a planned retrospective observational study with no results yet posted; it represents early-stage epidemiological work without outcome data.
As stated by the source record.
Quoted from the source exactly as published.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT07082465). This is a study registration, not published results. Lead sponsor: University of Oxford. Recruitment status: ACTIVE_NOT_RECRUITING. Study type: OBSERVATIONAL. Enrollment: 108000 participants (ESTIMATED). Conditions: Drug Resistance, Bacterial, Bacteremia. Primary outcome measures: New antimicrobial-resistant bloodstream infection , 6 years; In-hospital 30-day mortality , 6 years. Brief summary: The main goal of this retrospective observational study is to understand how stepping down antibiotic treatment (called antibiotic de-escalation) affects patients who receive it compared to those who don't after received a short-course (≤7 days) of parenteral antibiotics. The investigators will use past medical records from four public referral hospitals in Thailand from the year 2019 to 2024. The investigators will firstly evaluate which types of patients are more likely to receive antibiotic de-escalation. Then, the investigators will estimate the impact of antibiotic de-escalation, while taking those differences into account. This way, it will help us understand the impact of antibiotic de-escalation in real-world clinical practice. The investigators also aim to assess how accurate automated outbreak detection systems are at detecting outbreaks, evaluate patterns of antimicrobial use and antimicrobial-resistant infections, and develop new indicators for antimicrobial stewardship that are applicable for local and national actions in low and middle-income countries.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.