Alzheimer's Disease / AV-1451 · Observational Study

Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)

ClinicalTrials.gov · September 4, 2026

Preliminary Why this matters to you Expert discussion

Early or partial results. Treat as a signal, not a conclusion.

AI Summary

This is a planned prospective observational cohort study registered to characterize tau PET/CT imaging patterns and their relationship to clinical and cognitive phenotypes in older adults with MCI or Alzheimer's Disease. The study is currently recruiting and has not yet produced results; it is in the data collection phase.

What was studied

Observational. Alzheimer's Disease; age from 18 Years; to 120 Years. Intervention: AV-1451. n = 100. 2 sites: United States.

Key findings

Safety

Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.

Who this may help

No clinical impact can be assessed from this registry record, as no results have been reported. The study aims to provide insight into phenotypic variability of Alzheimer's Disease and related pathologies, but outcomes remain pending.

Plain-language summary

This is a recruiting observational cohort study with no results posted; it is an early-phase data collection effort designed to characterize tau PET patterns and their relationship to clinical phenotypes in cognitive impairment.

Study design

As stated by the source record.

MethodsCohort model. Cross Sectional time perspective. Primary outcome measure: Clusters based on spatial pattern and extent of T-N Mismatch (assessed at 5 years)

DesignObservational

PopulationAlzheimer's Disease; age from 18 Years; to 120 Years

Sample size100

InterventionAV-1451

Setting2 sites: United States

Reported figures

Quoted from the source exactly as published.

Planned enrollment100

Primary outcome measureClusters based on spatial pattern and extent of T-N Mismatch at 5 years

Study phaseObservational

Clinical bottom line

Caveats

This is a registry record only; no results, effect sizes, or outcome data are reported.
Study is still recruiting; enrolment and follow-up ongoing.
Primary outcome is clustering of tau PET patterns, not a clinical endpoint; clinical relevance of clusters unknown.
No control or comparator group; observational design limits causal inference.

Evidence assessment

Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.

Study design

moderate

Prospective observational cohort without control group; no randomization or blinding.

Directness

moderate

Direct measurement of tau PET imaging; clinical outcomes and cognitive data collected alongside.

Consistency

insufficient

Registry record only; no results posted for comparison or consistency assessment.

Risk of bias

insufficient

No methods or results detail provided to assess risk of bias; recruitment ongoing.

Sample adequacy

limited

Planned enrollment 100 participants; modest sample for phenotypic clustering and subgroup analysis.

What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.

Source abstract

Registry record from ClinicalTrials.gov (NCT05658913). This is a study registration, not published results. Lead sponsor: University of Pennsylvania. Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 100 participants (ESTIMATED). Conditions: Alzheimer's Disease. Interventions: DRUG: AV-1451. Primary outcome measures: Clusters based on spatial pattern and extent of T-N Mismatch , 5 years. Brief summary: To collect Tau PET/CT imaging in older adults diagnosed with Mild Cognitive Impairment (MCI) or Alzheimer's Disease (AD) in the Mismatch Prospective Cohort Study (MPC-Tau) study to determine relationship to clinical, cognitive, and other biomarker data. Findings from this study will likely provide insight into the phenotypic variability of Alzheimer's Disease and other related pathologies.

Follow from this

Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.

NCT05658913Alzheimer's DiseaseUniversity of PennsylvaniaAV-1451