Animal organoids as models for integrated One Health research

AI Summary

This is a narrative review that synthesizes the emerging use of animal organoid systems as in vitro models to advance One Health objectives. The review identifies potential applications in zoonotic disease, antimicrobial resistance, and pandemic preparedness but does not report empirical data, effect sizes, or clinical validation of these models.

Plain-language summary

This is a narrative review outlining potential applications of animal organoids for One Health research; it raises questions and describes methodologies rather than reporting empirical results or clinical outcomes.

Study design

As stated by the source record.

Clinical bottom line

This review outlines a methodological framework rather than clinical evidence. Clinicians and researchers should regard it as exploratory guidance on emerging in vitro tools; practical utility requires empirical validation in specific disease or resistance contexts.

Caveats

• No primary empirical results, effect sizes, or comparative validations are reported
• Generalizability of organoid findings to in vivo animal and human disease remains unquantified
• No assessment of organoid predictive accuracy, cost, or practical feasibility for One Health applications is provided
• The abstract does not specify which organoid types have been developed or their current stage of standardization

Evidence assessment

Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.

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