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Life sciences · Interventional Study
ClinicalTrials.gov · September 14, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07817667). This is a study registration, not published results. Lead sponsor: Assistance Publique Hopitaux De Marseille. Recruitment status: NOT_YET_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 100 participants (ESTIMATED). Conditions: Cardiac Surgery. Interventions: PROCEDURE: Epicardial adipose tissue biopsy; PROCEDURE: Thoracic subcutaneous adipose tissue biopsy. Primary outcome measures: Effect of epicardial and subcutaneous adipose tissue-derived extracellular vesicles on inflammatory and beiging-related gene and protein expression , Cardiac surgery. Brief summary: The FIRST study is a monocentric observational pilot study investigating the role of extracellular vesicles (EVs) derived from epicardial adipose tissue (EAT) in cardiovascular complications associated with obesity. EVs isolated from epicardial and subcutaneous adipose tissues obtained during cardiac surgery in adults and children will be analyzed for their molecular composition and biological activity. The study will evaluate their effects on inflammation and adipocyte beiging pathways in hMADS cells and monocyte-derived macrophages, and explore associations between EV characteristics and coronary perivascular inflammation assessed by CT imaging. Findings may improve understanding of the immunometabolic mechanisms linking EAT to cardiovascular disease.