Life sciences · Preprint
arXiv · September 10, 2026
Posted before peer review. The findings may change or fail to hold.
This preprint presents a generalized score matching framework for parameter estimation on convex domains, derived from Minimum Probability Flow learning. The authors establish that the objective is a proper local scoring rule of second-order with theoretical guarantees of density recovery, convexity for exponential family models, and consistency of finite-sample estimators. Experimental results on synthetic exponential family densities and a generative modeling task are reported, but the work remains unrefereed.
Theoretical methods paper with experimental validation. Intervention: Generalized score matching objective for parameter estimation on convex domains.
Generalized score matching objective derived as proper local scoring rule of second-order, guaranteeing true density recovery when minimized For exponential family models, objective shown to be convex with consistent finite-sample estimators under standard regularity conditions Framework unifies classical score matching and domain-adapted variants for non-negative data on convex subsets of ℝ^d
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Unrefereed methodological work on score matching for parameter estimation; presents theoretical results and experimental validation but has not undergone peer review.
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Maximum likelihood (ML) estimation is a principled and statistically efficient approach for learning probabilistic models. However, for unnormalized models, ML estimation requires evaluating the partition function and differentiating through it, which may not always be tractable. Score matching provides a practically viable alternative that circumvents this obstacle by fitting the score in a way that eliminates dependence on the normalizing constant. We derive the generalized score matching objective on a convex subset of $\mathbb{R}^{d}$ constructively starting from Minimum Probability Flow (MPF) learning, and show how classical score matching as well as domain-adapted variants for non-negative data arise naturally within the proposed framework. We show that the resulting objective is a {\it proper local scoring rule} of second-order, which provides the theoretical guarantee that the true density is recovered when the objective is minimized. Furthermore, for a model belonging to the exponential family, we establish convexity of the objective together with consistency of the finite-sample estimator under standard regularity conditions. Our derivation sheds new light on the scope and applicability of generalized score matching in various problem settings. We compare generalized score matching-based estimators on constrained domains, where the partition function is analytically intractable. We provide experimental results on parameter estimation for model densities belonging to the exponential family defined over convex subsets of $\mathbb{R}^{d}$, and a generative modeling use-case to demonstrate broader applicability of the proposed generalized score matching framework.
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