Life sciences · Observational Study
ClinicalTrials.gov · November 2, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT07227961). This is a study registration, not published results. Lead sponsor: University of Calgary. Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 800 participants (ESTIMATED). Conditions: Sarcoma, Giant Cell Tumor of Bone. Interventions: PROCEDURE: Surgery. Primary outcome measures: Step count , From enrolment to two years postoperative; Distance travelled , From enrolment two years postoperative; Move time , From enrolment two years postoperative; Flights of stairs climbed , From enrolment to two years postoperative; Walking Steadiness , From enrolment two years postoperative; Walking asymmetry , From enrolment two years postoperative; Double Support Time , From enrolment two years postoperative; Walking Speed , From enrolment two years postoperative; Step Length , From enrolment two years postoperative; Heart rate variability , From enrolment to two years postoperative; PROMIS Physical Function , From enrolment to two years postoperative; PROMIS Upper Extremity Function , From enrolment to two years postoperative; PROMIS Pain Interference , From enrolment to two years postoperative; PROMIS Global Health , From enrolment to two years postoperative; PROMIS Self Efficacy , From enrolment to two years postoperative; Toronto Extremity Salvage Score Lower Extremity , From enrolment to two years postoperative; Toronto Extremity Salvage Score Upper Extremity , From enrolment to two years postoperative; Demographic Survey , Enrolment. Brief summary: Sarcoma is a rare form of bone and soft tissue cancer, making up about 1% of all adult cancers. Management typically involves radiation therapy, chemotherapy, and surgical resection. Surgery is central to the treatment of bone and soft tissue sarcoma, yet post-surgical recovery is difficult to measure because of disease rarity, multiple different tumor types, and treatment variation. Therefore, the overall goal of the study is to use patient reported outcome measures and mobility data to define recovery trajectories in sarcoma patients undergoing surgery, and to evaluate a novel smartphone application (app) entailed Activation Health for collecting these data. Participants will download the Activation Health app on their smartphone. A demographics survey and multiple patient reported outcome measures will be administered remotely through the Activation Health app. Surveys will be completed preoperatively and at 6 weeks, 12 weeks, 6 months 12 months, 16 months, 20 months, and 24 months postoperatively. Additionally, the app will passively track mobility metrics such as daily step count, stairs climbed, and gait parameters throughout the study period. At the end of study participation, an additional surveys will be administered assess participant phone use habits and app function.