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Ovarian Cancer Diagnosis and Treatment / Parvovirus B19 Infection Studies · Journal article
Cureus · August 8, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a case report of pseudo-pseudo Meigs' syndrome (PPMS) in a 26-year-old woman with SLE presenting with pleural effusion, ascites, and elevated CA-125. The patient responded to prednisolone and hydroxychloroquine with complete resolution of pleural effusion. The report is descriptive and raises awareness of a rare SLE manifestation but provides no quantitative efficacy data, comparator, or systematic evidence.
Case report. 26-year-old woman with systemic lupus erythematosus presenting with dyspnea and pleuritic chest pain. Intervention: Prednisolone and hydroxychloroquine. n = 1.
26-year-old woman with left-sided pleural effusion diagnosed with SLE-associated PPMS Laboratory findings and imaging ruled out infectious and malignant causes Treatment with prednisolone and hydroxychloroquine resulted in marked clinical and serological improvement with complete resolution of pleural effusion
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For clinicians evaluating patients with SLE and pleural effusion combined with ascites and elevated CA-125, this report highlights PPMS as a diagnostic consideration after exclusion of infectious and malignant causes. However, a single case does not establish prevalence, optimal diagnostic criteria, or treatment protocols, and broader evidence is needed before changing practice.
Single case report of a rare SLE manifestation with clinical response to treatment; describes diagnosis and management but lacks comparative data, control group, or systematic evidence of efficacy.
As stated by the source record.
Quoted from the source exactly as published.
For clinicians evaluating patients with SLE and pleural effusion combined with ascites and elevated CA-125, this report highlights PPMS as a diagnostic consideration after exclusion of infectious and malignant causes. However, a single case does not establish prevalence, optimal diagnostic criteria, or treatment protocols, and broader evidence is needed before changing practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Pseudo-pseudo Meigs' syndrome (PPMS), also known as Tjalma syndrome, is a rare manifestation of systemic lupus erythematosus (SLE) characterized by pleural effusion, ascites, and elevated cancer antigen 125 (CA-125) levels in the absence of ovarian tumors. We report the case of a 26-year-old woman who presented with dyspnea and pleuritic chest pain. On evaluation, she was found to have a left-sided pleural effusion. Further investigations confirmed SLE. Laboratory findings and imaging studies ruled out infectious and malignant causes, leading to a diagnosis of PPMS by exclusion. Treatment with prednisolone and hydroxychloroquine (HCQ) resulted in marked clinical and serological improvement, with complete resolution of the pleural effusion. Additionally, we discuss the key differences between Meigs' syndrome and PPMS and compare this case with others reported in the literature. In patients with SLE presenting with pleural effusion, ascites, and elevated CA-125 levels, PPMS should be suspected. Diagnosis involves ruling out infectious and malignant causes through fluid analysis and imaging studies. This condition usually responds well to immunosuppressive therapy.
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