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Life sciences · Interventional Study
ClinicalTrials.gov · September 30, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT06758206). This is a study registration, not published results. Lead sponsor: Federal University of Vicosa. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 64 participants (ACTUAL). Conditions: Depressive Symptoms, Physical Function, Executive Function, Resistance Training. Interventions: BEHAVIORAL: Flywheel Resistance Training; BEHAVIORAL: Traditional resistance training. Primary outcome measures: Changes in baseline depressive symptoms at nine months. , Baseline, 4 and 9 months; Maximum isometric voluntary contraction , Baseline, 4 and 9 months; Muscle power , Baseline, 4 and 9 months; 1RM test , Baseline, 4 and 9 months; Change in baseline test Time up and go at nine months. , Baseline, 4 and 9 months; Change in baseline 30-s chair stand at nine months , Baseline, 4 and 9 months; Change in baseline 30-s arm curl at nine months , Baseline, 4 and 9 months; Change in baseline 6-min walk at nine months , Baseline, 4 and 9 months; Change in baseline chair sit-and-reach at nine months , Baseline, 4 and 9 months; Change in baseline back scratch at nine months , Baseline, 4 and 9 months; Change in baseline 8-foot up-and-go at nine months , Baseline, 4 and 9 months; Change in Inhibitory control at nine months , Baseline, 4 and 9 months; Change in Working memory at nine months , Baseline, 4 and 9 months; Change in Cognitive flexibility at nine months , Baseline, 4 and 9 months. Brief summary: There are easily accessible and safe strategies, such as resistance training, that can contribute to reducing depressive symptoms and preserving physical and executive function in older women. Resistance training is defined as exercises performed either in water or on land, involving the use of a constant load or uniform weight, regardless of the training program. Various types of resistance training equipment are available, including free weights, pneumatic resistance machines, elastic bands, or even body weight. Specifically, eccentric muscle action occurs when the force applied to the muscle exceeds the momentary force produced by the muscle itself, resulting in the forced elongation of the muscle-tendon system during contraction. To date, evidence from randomized clinical trials has compared the effectiveness of aerobic, resistance, and Pilates exercises in reducing depressive symptoms and improving physical and executive function in older women. While experimental studies have demonstrated the efficacy of physical exercise, the effect of long-term eccentrically reinforced resistance training on depressive symptoms, physical function, and executive function in sedentary older women remains unclear. Therefore, this study aims to evaluate the safety and effect of eccentrically reinforced resistance exercise versus traditional resistance training on depressive symptoms, physical and executive function, quality of life, different manifestations of muscle strength, body composition, vital signs, abdominal circumference, fall risk, and fatigue symptoms in sedentary older women over a 9-month period.