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Life sciences · Interventional Study
ClinicalTrials.gov · October 7, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT04599764). This is a study registration, not published results. Lead sponsor: Anhui Medical University. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 60 participants (ACTUAL). Conditions: Transcranial Direct Current Stimulation, Functional Magnetic Resonance Imaging, Early Alzheimer's Disease. Interventions: OTHER: HD-tDCS; OTHER: computer-based cognitive training; OTHER: Sham tDCS; BEHAVIORAL: Control cognitive training. Primary outcome measures: Changes assessed by Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) , changes from baseline at 14 days and 12 weeks post-treatment. Brief summary: This completed randomized trial evaluated the clinical and neural effects of high-definition transcranial direct current stimulation (HD-tDCS) combined with computerized cognitive training in patients with Alzheimer's disease. Participants were assigned to active HD-tDCS plus computerized cognitive training, computerized cognitive training control, or active HD-tDCS control. The study assessed whether combined neuromodulation and cognitive training produced greater cognitive and clinical benefit than either component condition, and whether treatment-related benefit was associated with changes in brain network organization.