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Life sciences · Preprint
arXiv · October 10, 2026
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Large language model (LLM)-based AI Scientists advance scientific discovery, yet they suffer from inefficiencies due to noisy observations. Existing principle-evolving agents act on every anomaly, leaving its source unresolved: a new mechanism or an evaluation artifact, so invalid revisions bias evolution. To address this, we formulate revision as evidence admission: anomalies steer search immediately, but only independently verified evidence may rewrite persistent principles, and contradicted principles are retracted. We realize this in TRIAGE-PIEVO , which pairs an anomaly-responsive search portfolio with a staged verification gate that alone controls what enters principle state. Across four scientific tasks with three backbones, TRIAGE-PIEVO (1) attains the highest average solution quality with +7.5%~11.8% over the strongest baseline per backbone, matching the strongest baseline's full-budget quality with one-third of the evaluation budget on Qwen3-235B; and additional stress tests and cross-harness deployment demonstrate that (2) in constructed stress tests, it admits none of the corrupted, hidden-source, or exploit evidence that ungated variants admit, while missing no planted mechanism, and (3) plugged unchanged into three external research harnesses, it cuts false evidence admissions by over 60% and raises verified scores by 31%~43%.