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Life sciences · Interventional Study
ClinicalTrials.gov · October 7, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07133542). This is a study registration, not published results. Lead sponsor: Hainan Normal University. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 48 participants (ACTUAL). Conditions: Overweight and/or Obesity. Interventions: BEHAVIORAL: Dynamic Matrix Management for Weight Control (DMM-WC); BEHAVIORAL: Standard Aerobic Prescription. Primary outcome measures: Body Mass Index (BMI) , Baseline, Week 8; Body weight at week 8. , Week 8; additional measurements at baseline and week 4.. Brief summary: This single-center, two-arm, parallel exploratory randomized controlled trial compared adaptive multicomponent weight management guided by a 3×3 waist circumference-body fat percentage (WC-BFP) phenotype classification with structured aerobic exercise over 8 weeks. Forty-eight university students with overweight, central obesity, or elevated BFP were randomized 1:1. The adaptive intervention combined aerobic, resistance, and flexibility exercise with phenotype-matched nutritional and behavioral support; WC and BFP were reassessed every 2 weeks to guide prescription adjustments. The comparator involved 3-5 aerobic exercise sessions per week, totaling more than 150 minutes per week, with progressive intensity from 40%-50% to 60%-80% of heart rate reserve. Both groups received individualized minimum daily energy-intake targets, wearable monitoring, online exercise and dietary logging, and remote supervision. Anthropometric outcomes and exercise self-efficacy were assessed at baseline and weeks 4 and 8; exercise adherence was assessed at weeks 4 and 8. The manuscript identifies week-8 body weight as the primary outcome, five additional anthropometric measures as secondary outcomes, and behavioral measures and phenotype transitions as supportive or exploratory outcomes.