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Life sciences · Interventional Study
ClinicalTrials.gov · September 17, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT06971549). This is a study registration, not published results. Lead sponsor: The Hong Kong Polytechnic University. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 1 participants (ACTUAL). Conditions: Depression. Interventions: OTHER: Accelerated iTBS. Primary outcome measures: Oxygenated and deoxygenated hemoglobin (HbO and HbR) change compared to baseline , Before, during and immediately after the intervention; Hamilton Depression Rating Scale (HAM-D) , through study completion, an average of 5 days. Brief summary: This study will investigate the cortical hemodynamic response variability of an accelerated form of TBS stimulation over left dorsolateral prefrontal cortex (DLPFC) using a concurrent TBS/fNIRS setup. The accelerating TMS protocol that will be used in this study is similar to the Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT), i.e., fifty iTBS sessions (1,800 pulses per session, 50-minute intersession interval) will be delivered as 10 daily sessions over 5 consecutive days at 90% resting motor threshold. The investigators will recruit a depressed patient and conduct a concurrent iTBS/fNIRS protocol for each iTBS session. Moreover, the depression symptoms of the patient will be assessed before and after treatment.