Loading
Life sciences · Journal article
International Journal of Science and Research Archive · September 18, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Journal article.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Background: Primary Sclerosing Cholangitis (PSC) is a progressive cholangiopathy characterized by multifocal stricturing and fibrosis of the intrahepatic and/or extrahepatic bile ducts. The disease generally follows an indolent course over several years; however, rapidly progressive variants leading to early cirrhosis and liver transplantation are rarely reported, particularly in young woman without associated inflammatory bowel disease (IBD). Case Presentation: A 23-year-old woman presented with jaundice and pruritus in May 2025. Initial investigations demonstrated cholestatic liver dysfunction with elevated bilirubin and alkaline phosphatase levels. Viral, autoimmune, infectious, and metabolic etiologies were excluded. MRCP revealed multifocal biliary strictures with non-visualization of the common hepatic duct and bilateral hepatic ducts, associated with lobar atrophy and caudate lobe hypertrophy, highly suggestive of primary sclerosing cholangitis. Liver biopsy demonstrated biliary-pattern injury with periductal fibrosis consistent with PSC. Despite treatment with ursodeoxycholic acid and symptomatic therapy, she experienced rapid progression of jaundice and cholestasis within six months. Repeat evaluation revealed worsening of hyperbilirubinemia, coagulopathy, and established biliary cirrhosis. Following multidisciplinary assessment, the patient underwent deceased donor orthotopic liver transplantation with hepaticojejunostomy in December 2025. She remains clinically stable on follow-up. Incidentally, her father had ulcerative colitis for 25 years, developed sigmoid colon cancer in 2020 resulting in a total proctocolectomy with ileal pouch-anal anastomosis (IPAA). Conclusion: This case highlights an aggressive phenotype of PSC with unusually rapid progression to end-stage liver disease in the absence of IBD. Early recognition of aggressive disease behavior and timely referral for transplantation is essential for favorable outcome.