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Life sciences · Interventional Study
ClinicalTrials.gov · October 2, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT06412315). This is a study registration, not published results. Lead sponsor: University of Oxford. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 54 participants (ESTIMATED). Conditions: Emotional Processing, Cognition, Mood Disorders, Depressive Disorder, Depression. Interventions: DRUG: Citalopram; DRUG: Placebo. Primary outcome measures: Neural measures: fMRI BOLD univariate analysis , 3 hours after dosing for approximately 1 hour; Neural measures: fMRI BOLD multivariate analysis , 3 hours after dosing for approximately 1 hour. Brief summary: The goal of this study is to investigate how a common antidepressant citalopram (which increases the levels of the chemical messenger serotonin), affects how a key area of the brain involved in depression (the amygdala) responds to emotional information. Healthy participants will undergo medical and psychiatric health screening, after which they will be assigned to receive either a single dose of citalopram (20mg) or placebo, and undergo brain scanning (7T fMRI) whilst viewing emotional faces. Since the scan uses high field strength, the investigators will be able to see effects of citalopram on different subfields within the amygdala which will help to understand how citalopram might be working.