Loading
Remotely Supervised Transcranial Direct Current Stimulation- Active / Progressive Aphasia / Primary Progressive Aphasia(ppa) · Interventional Study
ClinicalTrials.gov · September 4, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a clinical trial registration for a remotely-delivered, sham-controlled study of transcranial direct current stimulation combined with virtual speech-language therapy in logopenic variant primary progressive aphasia. The trial is currently recruiting and has not yet reported results. No efficacy or safety data are available from this registry record.
Interventional, Randomized, Parallel, Triple masking, Treatment purpose. Primary Progressive Aphasia(PPA), Progressive Aphasia, Progressive Aphasia in Alzheimer's Disease, Logopenic Progressive Aphasia (LPA), Logopenic Variant Prima…; age from 40 Years. Intervention: Language Therapy with Active Stimulation. Compared with: Language Therapy with Sham Stimulation — Sham Comparator. n = 80. 2 sites: United States.
This is a clinical trial registration for a remotely-delivered, sham-controlled study of transcranial direct current stimulation combined with virtual speech-language therapy in logopenic variant primary progressive aphasia. The trial is currently recruiting and has not yet reported results. No efficacy or safety data are available from this registry record.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
No clinical impact can be assessed until results are posted. This registration establishes the planned structure for a feasibility and efficacy trial in a rare, progressive condition for which evidence-based neuromodulation approaches are limited.
This is a recruitment-phase trial registration with no posted results; it describes a planned feasibility and efficacy study combining neuromodulation with speech therapy in a rare progressive language disorder.
As stated by the source record.
Quoted from the source exactly as published.
No clinical impact can be assessed until results are posted. This registration establishes the planned structure for a feasibility and efficacy trial in a rare, progressive condition for which evidence-based neuromodulation approaches are limited.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT07260253). This is a study registration, not published results. Lead sponsor: Maya Henry. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 80 participants (ESTIMATED). Conditions: Primary Progressive Aphasia(PPA), Progressive Aphasia, Progressive Aphasia in Alzheimer's Disease, Logopenic Progressive Aphasia (LPA), Logopenic Variant Primary Progressive Aphasia, Logopenic Variant of Primary Progressive Aphasia (LPA). Interventions: BEHAVIORAL: Lexical Retrieval Cascade Treatment; DEVICE: Remotely Supervised Transcranial Direct Current Stimulation- Active; DEVICE: Remotely Supervised Transcranial Direct Current Stimulation - Sham. Primary outcome measures: Change in spoken naming , change from pre-treatment to one month and three months after onset of treatment in each phase (stimulation and sham). Brief summary: The goal of this clinical trial is to learn whether home-based brain stimulation combined with virtual speech-language therapy can improve communication abilities in adults with logopenic variant primary progressive aphasia (lvPPA), a language disorder most often caused by Alzheimer's disease. The main questions the study aims to answer are: * Is combining remotely supervised transcranial direct current stimulation (tDCS) with virtual speech-language therapy feasible and acceptable for people with lvPPA? * Does this combined treatment lead to improvements in communication compared to speech-language therapy with sham (placebo) stimulation? * Do individual brain characteristics help predict who benefits most from this treatment? Researchers will compare participants who receive active tDCS plus virtual speech-language therapy to participants who receive sham (placebo) tDCS plus virtual speech-language therapy to see if active brain stimulation enhances communication outcomes. Participants will: * Complete speech-language therapy sessions delivered by video visit. * Receive either active or sham tDCS that is remotely supervised and completed at home. * Complete language and cognitive testing before and after treatment. * Undergo brain imaging and other assessments to help understand treatment response.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.