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Breast Cancer Treatment Studies / Breast Lesions and Carcinomas · Journal article
Asian Journal of Advanced Research and Reports · September 9, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a single-centre retrospective case series of 101 young women (≤40 years) with breast cancer treated in Senegal, describing high rates of locally advanced disease and poor survival. The study reports descriptive epidemiology and treatment patterns without a comparator arm; the findings illustrate aggressive presentation in a resource-limited setting but do not establish causation or compare outcomes to alternative strategies.
Retrospective cross-sectional study. Women aged 40 years or younger with histologically confirmed breast cancer receiving care at the Regional Hospital Center of Thiès, Senegal. Setting: single regional teaching hospital in Thiès, West Africa.. Intervention: Multimodal treatment: chemotherapy (neoadjuvant or adjuvant), surgery, radiotherapy, and/or hormone therapy as clinically indicated.. n = 101. Regional Hospital Center of Thiès, Senegal.
Mean age 34 years; mean delay to consultation 10.53 months 56.4% had T4 disease, 73.3% had lymph node involvement, 24.75% had metastases at diagnosis Invasive ductal carcinoma of no special type in 96.04% of cases; SBR grade II in 62.4%
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This report illustrates the aggressive presentation and poor outcomes of early-onset breast cancer in a West African setting, highlighting diagnostic delays and treatment constraints. Clinicians should recognize these patterns as potentially informative for resource-limited settings but note the absence of a comparator group or adjustment for confounders limits the ability to identify modifiable drivers of poor survival.
Single-centre retrospective descriptive study of breast cancer in young women with survival outcomes, lacking a comparator group and control arm; useful for understanding local epidemiology but insufficient design to drive clinical practice change.
As stated by the source record.
Quoted from the source exactly as published.
This report illustrates the aggressive presentation and poor outcomes of early-onset breast cancer in a West African setting, highlighting diagnostic delays and treatment constraints. Clinicians should recognize these patterns as potentially informative for resource-limited settings but note the absence of a comparator group or adjustment for confounders limits the ability to identify modifiable drivers of poor survival.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Introduction: Breast cancer in young women represents an emerging public health concern. Its impact is often poorly understood and underestimated. Objectives: This study aimed to investigate the diagnostic and prognostic aspects of breast cancer in women aged 40 years or younger who were treated at the Regional Hospital Center of Thiès. Patients and Methods: This retrospective cross-sectional study was conducted from January 5, 2017, to June 8, 2023. It included 101 women aged 40 years or younger with histologically confirmed breast cancer who received care at the Regional Hospital Center of Thiès. Results: The mean age of the patients was 34 years, and the mean delay to consultation was 10.53 months. The disease was predominantly locally advanced: 56.4% of patients had T4 disease, 73.3% had lymph node involvement, and 24.75% had metastases at diagnosis. Invasive ductal carcinoma of no special type was the most frequent histological type, accounting for 96.04% of cases, and SBR grade II was observed in 62.4%. Immunohistochemistry identified luminal B disease in six patients (5.94%) and triple-negative disease in four (3.96%). All patients received chemotherapy; 89.11% received neoadjuvant chemotherapy and 7.9% received adjuvant chemotherapy. Surgery was performed in 44 patients (43.56%). Radiotherapy was administered to 14 patients (13.86%), and hormone therapy was indicated for nine patients (8.9%). Thirty patients had died by the end of the study. Overall survival was 65.6% at 3 years and 60.1% at 5 years. Conclusion: Breast cancer is increasingly prevalent among young women and presents with a more aggressive profile and a poorer prognosis than in older women. Management remains challenging and may be complicated by diagnostic delays, poor therapeutic adherence, and a persistently low survival rate.
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