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Life sciences · Interventional Study
ClinicalTrials.gov · November 2, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07910747). This is a study registration, not published results. Lead sponsor: University of Sao Paulo. Recruitment status: NOT_YET_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 60 participants (ESTIMATED). Conditions: Obesity (Disorder), Inflammation. Interventions: DIETARY_SUPPLEMENT: Taurine supplementation; DRUG: Placebo Supplementation; BEHAVIORAL: High-intensity interval training (HIIT). Primary outcome measures: Changes in diurnal variation of BMAL1 gene expression in peripheral blood mononuclear cells (PBMCs) , Baseline (Week 0) and post-intervention (Week 12).. Brief summary: The goal of this clinical trial is to evaluate whether taurine supplementation, alone or combined with high-intensity interval training (HIIT) performed in morning or evening, affects circadian clock gene expression and inflamatory markers in adult women with obesity. The main questions it aims to answer are: * Is the modulation of circadian clock gene expression associated with the anti-inflammatory effects of taurine? * Does the timing of HIIT (morning or evening) affect circadian clock gene expression and inflammatory and metabolic responses? Researchers will compare six groups to evaluate the effects of taurine supplementation, HIIT performed in the morning or evening, and their combination. Participants will: * Take taurine (3g/day) or a matching placebo for 12 weeks, according to their assigned group; * Perform HIIT in the morning or evening if assigned to an exercise group; * Attend study visits at baseline (week 0) and after 12 weeks for assessments of metabolic and inflammatory parameters, circadian clock gene expression in peripheral blood mononuclear cells (PBMCs), as well as anthropometric measures, body composition and cardiorrespiratory fitness.