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Life sciences · Observational Study
ClinicalTrials.gov · October 9, 2026
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Observational Study.
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Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
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Registry record from ClinicalTrials.gov (NCT07192770). This is a study registration, not published results. Lead sponsor: Ankara Etlik City Hospital. Recruitment status: COMPLETED. Study type: OBSERVATIONAL. Enrollment: 190 participants (ACTUAL). Conditions: Solid Tumors, Chemotherapy-induced Neutropenia. Interventions: BIOLOGICAL: Filgrastim (G-CSF); DRUG: Naproxen; DRUG: Loratadine. Primary outcome measures: Change in Numeric Rating Scale (NRS) Bone Pain Score From Baseline to Study Day 8 , Baseline and study day 8. Brief summary: This prospective two-center observational cohort study evaluated G-CSF-related bone pain and multidimensional symptom burden in adults with solid tumors receiving chemotherapy and filgrastim prophylaxis. Participants received one of two physician-selected supportive-care strategies as part of routine clinical practice: naproxen alone or naproxen plus loratadine. Pain was assessed using an 11-point Numeric Rating Scale (NRS) at baseline and on study day 8, with study day 1 defined as the first day of filgrastim administration. Patient-reported outcomes included the EORTC QLQ-C30, GAD-7, Beck Depression Inventory, and Pittsburgh Sleep Quality Index. A total of 190 patients were enrolled at Ankara Etlik City Hospital and Gazi University Faculty of Medicine.