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Life sciences · Interventional Study
ClinicalTrials.gov · October 8, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07478653). This is a study registration, not published results. Lead sponsor: Oelisoa Andriankaja. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 50 participants (ESTIMATED). Conditions: Obesity, Dental Care for Children. Interventions: PROCEDURE: Dental Cleaning and Oral Hygiene Instruction (OHI); BEHAVIORAL: Oral Hygiene Instruction (OHI). Primary outcome measures: Change in gingival index , Baseline, 6 months, 12 months; Change in probing depth , Baseline, 6 months, 12 months; Change in BOP (Bleeding on probing) , Baseline, 6 months, 12 months; Change in Plaque Index , Baseline, 6 months, 12 months; Change in Clinical Attachment Level (CAL) , Baseline, 6 months, 12 months; Change in Gingival Margin Position (GM) , Baseline, 6 months, 12 months; Number of participants with Supragingival and Subgingival Calculus , Baseline, 6 months, 12 months; Change in Gingival Crevicular Fluid (GCF) , Baseline, 6 months, 12 months; Change in Bacterial Subgingival Biofilm , Baseline, 6 months, 12 months; Change in levels of Interleukin-1 beta (IL-1β) , Baseline, 6 months, 12 months; Change in levels of Tumor Necrosis Factor-alpha , Baseline, 6 months, 12 months; Change in levels of Interleukin-6 (IL-6) , Baseline, 6 months, 12 months; Change in levels of C-reactive protein (CRP) , Baseline, 6 months, 12 months; Change in levels of Soluble intercellular adhesion molecule-1 (sICAM-1) , Baseline, 6 months, 12 months; Change in levels of Soluble vascular cell adhesion molecule-1 (sVCAM-1) , Baseline, 6 months, 12 months; Change in levels of endocan , Baseline, 6 months, 12 months; Change in levels of Vascular Endothelial Growth Factor A (VEGF-A) , Baseline, 6 months, 12 months; Change in Oral Microbiome , Baseline, 6 months, 12 months; Change in active oral microbiome (RNA sequencing) , Baseline, 6 months, 12 months. Brief summary: The goal of this clinical trial is to assess whether adjunctive dental cleaning can enhance the effects of semaglutide in children with obesity. The main question\[s\] it aims to answer \[is/are\]: if dental cleaning will improve both oral health and metabolic outcomes beyond the effects of semaglutide alone. Participants will receive either dental cleaning and oral hygiene instruction or oral hygiene instruction alone.