Life sciences · Interventional Study
ClinicalTrials.gov · November 6, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07184866). This is a study registration, not published results. Lead sponsor: Institute of Liver and Biliary Sciences, India. Recruitment status: NOT_YET_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 110 participants (ESTIMATED). Conditions: Acute-on-Chronic Liver Failure (ACLF). Interventions: DRUG: Vitamin C; OTHER: Standard of Care (SOC). Primary outcome measures: Resolution of septic shock at 96 hours (Day 4) , Day 4 (96 hours) after randomization. Brief summary: This study is testing whether Vitamin C can help improve kidney function and survival in very sick patients with liver disease. Patients with acute-on-chronic liver failure (ACLF) often develop serious infections that can lead to septic shock and kidney injury, which are major causes of death. In this randomized controlled trial, patients with ACLF and septic shock will be assigned to receive either: 1. Standard medical treatment alone, or 2. Standard medical treatment plus intravenous Vitamin C. Vitamin C is a safe, inexpensive antioxidant that may reduce inflammation, improve circulation, and protect the kidneys. The study will compare how well patients recover from septic shock and kidney injury in the two groups. Blood and urine samples will also be collected to look for biological markers that can predict outcomes.