Life sciences · Preprint
arXiv · November 2, 2026
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We consider nonparametric maximum likelihood estimation of the intensity function of a Poisson process, allowing the intensity to depend on observed covariates. Such models describe how event rates vary with external conditions, including conditions under which the intensity becomes arbitrarily small or vanishes. However, risk analysis based on the Kullback-Leibler (KL) divergence typically requires the true intensity to be bounded away from zero, a restrictive assumption in applications. We develop a unified approach that avoids this assumption and derive an oracle inequality for the covariate-averaged Hellinger distance between the true intensity and the nonparametric maximum likelihood estimator (NPMLE). As an application of the oracle inequality, we establish convergence rates for NPMLEs based on deep neural networks (DNNs). Our results show that, as in nonparametric regression, the ability of DNNs to capture underlying structure leads to improved convergence rates. Specifically, DNN-based NPMLEs mitigate the curse of dimensionality when the true intensity has a compositional structure and automatically adapt to a low-dimensional Riemannian manifold structure of the event space. For intensity functions with a compositional structure, DNN-based NPMLEs achieve nearly minimax-optimal convergence rates without explicitly incorporating this structure into the network architecture. Simulations demonstrate that DNN-based estimators outperform kernel estimators in most settings, while manifold kernels remain competitive in some designs. Finally, we analyze stimulus-evoked neural spiking using data from the Allen Brain Observatory Visual Coding Neuropixels project. DNN-based NPMLEs provide better out-of-sample performance than a conditional kernel estimator, as evaluated by held-out log-likelihood.