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Life sciences · Observational Study
ClinicalTrials.gov · November 4, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Observational Study.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
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Registry record from ClinicalTrials.gov (NCT03268135). This is a study registration, not published results. Lead sponsor: IRCCS Policlinico S. Donato. Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 500 participants (ESTIMATED). Conditions: Heart Failure, Aortic Stenosis. Interventions: DIAGNOSTIC_TEST: measurement of RNAs. Primary outcome measures: Cardiac tissutal mRNAs signatures , from Year 1 to Year 3; Cardiac tissutal miRNAs signatures , from Year 1 to Year 3; Cardiac tissutal lncRNAs signatures , from Year 1 to Year 3. Brief summary: This study is aimed to investigate the global transcriptome in order to determine the expression profile of messenger RNAs (mRNAs), as well as long noncoding- (lncRNAs) and micro noncoding-RNAs (miRNAs) in heart failure (HF) and in aortic stenosis (AS). The aim is to clarify their role in cardiac disease pathogenesis, as well as their potential as biomarkers. To this purpose, both tissue and blood specimens will be collected and patients will be compared to individuals not affected by cardiovascular diseases.