Cancer, Stress, Anesthesia, and Immune Response / Advanced Breast Cancer Therapies · Journal article

Neuroscience in cancer care: ethical, legal, and societal challenges

Molecular Psychiatry · August 10, 2026

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Source abstract

Magnon C, Hondermarck H. The neural addiction of cancer. Nat Rev Cancer. 2023;23:317–34. Article CAS PubMed Google Scholar Xu M, Yu Y, Cao C. CGRP-mediated neural addiction in tumor dynamic remodeling. Trends Cancer. 2025;11:834–8. Article CAS PubMed Google Scholar Cao C. Targeting tumor-associated nerves enhances cancer immunotherapy. Neuron. 2025;113:3076–8. Article CAS PubMed Google Scholar Zhi X, Wu F, Qian J, Ochiai Y, Lian G, Malagola E, et al. Nociceptive neurons promote gastric tumour progression via a CGRP-RAMP1 axis. Nature. 2025;640:802–10. Article CAS PubMed PubMed Central Google Scholar Pu T, Sun J, Ren G, Li H. Neuro-immune crosstalk in cancer: mechanisms and therapeutic implications. Signal Transduct Target Ther. 2025;10:176. Article PubMed PubMed Central Google Scholar Zhang S, Yuan L, Lin P, Yang G, Zhou X, Xu J, et al. Cancer neuroscience: signaling pathways and new therapeutic strategies for cancer. Signal Transduct Target Ther. 2026;11:66. Article CAS PubMed PubMed Central Google Scholar Winkler F, Heuer S, Althammer F, Augustin H, Beleggia F, Demir IE, et al. Cancer neuroscience: the past, the present, and the road ahead. Cell. 2026;189:2464–89. Article CAS PubMed Google Scholar Liu QQ, Dong ZK, Wang YF, Jin WL. Reprogramming neural-tumor crosstalk: emerging therapeutic dimensions and targeting strategies. Mil Med Res. 2025;12:73. PubMed PubMed Central Google Scholar Lampros M, Vlachos N, Lianos GD, Bali C, Alexiou GA. Editorial: drug repurposing for cancer treatment: current and future directions. Front Oncol. 2025;15:1550672. Article CAS PubMed PubMed Central Google Scholar van der Vorst M, Neefjes ECW, Boddaert MSA, Verdegaal B, Beeker A, Teunissen SCC, et al. Olanzapine versus haloperidol for treatment of delirium in patients with advanced cancer: a phase III randomized clinical trial. Oncologist. 2020;25:e570–577. Article PubMed Google Scholar Bandos H, Torres-Saavedra PA, Culakova E, Gunn HJ, Lee MK, Duan F, et al. Best practices and pragmatic approaches for patient-reported outcomes and quality of life measures in cancer clinical trials. J Natl Cancer Inst Monogr. 2025;2025:14–21. Article PubMed PubMed Central Google Scholar Chu C, Artis D, Chiu IM. Neuro-immune interactions in the tissues. Immunity. 2020;52:464–74. Article CAS PubMed PubMed Central Google Scholar Xia Y, Sun M, Huang H, Jin WL. Drug repurposing for cancer therapy. Signal Transduct Target Ther. 2024;9:92. Article PubMed PubMed Central Google Scholar Crittenden D, Gallagher R, Milans Del Bosch F, Fox DM, Kleiman LB. Pathways for non-manufacturers to drive generic drug repurposing for cancer in the U.S. Front Pharmacol. 2024;15:1419772. Article PubMed PubMed Central Google Scholar Smit AK, Gokoolparsadh A, McWhirter R, Newett L, Milch V, Hermes A, et al. Ethical, legal, and social issues related to genetics and genomics in cancer: a scoping review and narrative synthesis. Genet Med. 2024;26:101270. Article CAS PubMed Google Scholar Savchuk S, Gentry KM, Wang W, Carleton E, Biagi-Junior CAO, Luthria K, et al. Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis. Nature. 2025;646:1232–42. Article CAS PubMed PubMed Central Google Scholar Ako T, Ørnskov MP, Lykke C, Sjøgren P, Kurita GP. Prevalence of opioid misuse in patients with cancer: a systematic review and meta-analysis. Br J Cancer. 2024;131:1014–20. Article PubMed PubMed Central Google Scholar Li Y, Na J, Zhong L, Zhao Y. Advances in the treatment of malignant tumors with neurological drugs. Discov Oncol. 2025;16:1346. Article PubMed PubMed Central Google Scholar Goering S, Klein E. Fostering neuroethics integration with neuroscience in the BRAIN initiative: comments on the NIH neuroethics roadmap. AJOB Neurosci. 2020;11:184–8. Article PubMed PubMed Central Google Scholar Download references

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Ding MaCanhui CaoCancer, Stress, Anesthesia, and Immune ResponseAdvanced Breast Cancer Therapies