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Life sciences · Interventional Study
ClinicalTrials.gov · October 15, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07875309). This is a study registration, not published results. Lead sponsor: University of Melbourne. Recruitment status: NOT_YET_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 240 participants (ESTIMATED). Conditions: Depression and Anxiety Symptoms, Multiple Sclerosis. Interventions: DEVICE: ACTION-MS website - an 8-week cognitive behavioural therapy intervention for depression.; DEVICE: The 'Health and Wellbeing in MS' website. Primary outcome measures: Depression, measured on Beck's Depression Inventory II , Baseline, post intervention (8 weeks) and 28-weeks follow up. Brief summary: Individuals with MS experience significantly high levels of depression which are higher than in any other chronic illness or neurological disorder. Depression can occur at any point in the course of the disease. Cognitive behavioural therapy (CBT) has been found to be effective in treating depression in people with MS. However, many individuals with MS who would benefit from CBT for depression do not participate in face-to-face treatment due to lack of clinician referral, accessibility, modality preference, cost, and mobility and travel issues due to health reasons. Given the acceptability and preference for telehealth treatment options, digital-based psychological interventions can be another appealing treatment option as these programs have the ability to deliver interactive CBT treatments for depression to individuals with MS at a time and location convenient to the individual. The current trial proposes to test the acceptability, effectiveness, satisfaction and cost-effectiveness of an 8-week online depression intervention targeting individuals with multiple sclerosis and compare this intervention with an 8-week online health and wellbeing in MS informational intervention.