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Transcranial Direct Current Stimulation / Sham Transcranial Direct Current Stimulation / Depression · Interventional Study
ClinicalTrials.gov · August 12, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a completed but unpublished registry record for a small, sham-controlled study of MRI-guided tDCS in major depression. The primary outcome is acute changes in brain functional connectivity measured by fMRI, a surrogate marker. Clinical results and effect sizes are not available in this registry entry.
Interventional, Randomized, Parallel, Single masking, Basic Science purpose. Depression; age from 18 Years; to 65 Years. Intervention: Active. Compared with: Sham — Sham Comparator. n = 26. 1 site: United States.
This is a completed but unpublished registry record for a small, sham-controlled study of MRI-guided tDCS in major depression. The primary outcome is acute changes in brain functional connectivity measured by fMRI, a surrogate marker. Clinical results and effect sizes are not available in this registry entry.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The clinical relevance of this study cannot be assessed from the registry record alone, as results and effect sizes on depressive symptoms are not reported. Publication of results is required to determine whether MRI-guided tDCS produces measurable neurobiological or clinical benefits.
This is a completed but unpublished registry record for a small intervention study (N=26) with surrogate neuroimaging endpoints; results are not yet reported.
As stated by the source record.
Quoted from the source exactly as published.
The clinical relevance of this study cannot be assessed from the registry record alone, as results and effect sizes on depressive symptoms are not reported. Publication of results is required to determine whether MRI-guided tDCS produces measurable neurobiological or clinical benefits.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT05090397). This is a study registration, not published results. Lead sponsor: Northwestern University. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 26 participants (ACTUAL). Conditions: Depression. Interventions: DEVICE: Transcranial Direct Current Stimulation; DEVICE: Sham Transcranial Direct Current Stimulation. Primary outcome measures: Changes in brain functional connectivity , Acute/immediate. Brief summary: The purpose of this research is to understand how a neurostimulation technique, transcranial electrical stimulation (tES), affects brain function in adults with major depression measured with functional magnetic resonance imaging (fMRI). This study targets a specific kind of tES called transcranial direct current stimulation (tDCS), where a mild, constant current is passed between electrodes placed on the scalp.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.