Alzheimer's Disease(ad) / Subjective Cognitive Decline (SCD) / None, this is a non-interventional observational study · Observational Study

InRAD Observational Study

ClinicalTrials.gov · August 13, 2026

Preliminary Why this matters to you Expert discussion

Early or partial results. Treat as a signal, not a conclusion.

AI Summary

This is a protocol and registry record for an international, non-interventional observational study of long-term disease outcomes and treatment safety in Alzheimer's disease, currently recruiting 50,000 participants. No results are reported in this registry entry; the study is ongoing and designed to collect real-world clinical data over 10 years to characterize disease progression and monitor treatment effectiveness and safety.

What was studied

Observational. Alzheimer's Disease(AD), Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Non-Alzheimer Degenerative Dementia. Intervention: Alzheimer's Disease Registry Participants. n = 50,000. 11 sites across 8 countries.

Key findings

Safety

Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.

Who this may help

This registry is designed to generate real-world evidence on disease progression patterns and treatment safety in AD across diverse geographic and clinical settings. Results, when available, may inform clinical practice regarding comparative treatment effectiveness and long-term disease course.

Plain-language summary

A registry record for a recruiting observational study with no published results; describes design and aims only, not outcomes or evidence of efficacy.

Study design

As stated by the source record.

MethodsCohort model. Prospective time perspective. Primary outcome measure: Changes in Alzheimer's Disease Clinical Staging over time (assessed at 10 years)

DesignObservational

PopulationAlzheimer's Disease(AD), Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Non-Alzheimer Degenerative Dementia

Sample size50,000

InterventionAlzheimer's Disease Registry Participants

Setting11 sites across 8 countries

Reported figures

Quoted from the source exactly as published.

Planned sample size50000

Primary outcome measureChanges in Alzheimer's Disease Clinical Staging over time

Follow-up duration10 years

Minimum follow-up frequencyat least once a year, or as frequently as needed for care

Clinical bottom line

Caveats

Registry record only; no results, interim analyses, or efficacy data are reported.
Selection bias and confounding inherent to observational design are not addressed in this record.
Specific eligibility criteria, enrolled sites, and detailed outcome assessment protocols are not provided in this excerpt.
Study is actively recruiting; enrollment and follow-up completion are ongoing and incomplete.

Evidence assessment

Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.

Study design

moderate

Non-interventional observational study; real-world data collection design is appropriate for safety and outcomes surveillance.

Directness

moderate

Directly addresses disease outcomes and treatment safety in routine clinical practice; outcomes measured over 10 years.

Consistency

insufficient

Registry record only; no results reported to assess consistency with prior work.

Risk of bias

insufficient

No results or analysis methods detailed; selection bias and confounding inherent to observational design unaddressed.

Sample adequacy

moderate

Planned enrollment 50,000 participants across global centers; adequately sized for observational outcomes surveillance.

What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.

Source abstract

Registry record from ClinicalTrials.gov (NCT07213700). This is a study registration, not published results. Lead sponsor: Stichting International Registry for Alzheimer's Disease and other Dementias Foundation. Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 50000 participants (ESTIMATED). Conditions: Alzheimer's Disease(AD), Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Non-Alzheimer Degenerative Dementia. Interventions: OTHER: None, this is a non-interventional observational study. Primary outcome measures: Changes in Alzheimer's Disease Clinical Staging over time , 10 years. Brief summary: The goal of this international observational study is to evaluate long-term disease outcomes and treatment safety in people with Alzheimer's disease (PwAD), by collecting real-world data from routine clinical practice across global clinical centers. The InRAD Registry Observational Study has several aims: * To collect medical information for many years from a large group of people with Alzheimer's disease. This will be used for research, which will support improved understanding about the disease. * To enable researchers to look at the effectiveness, usefulness and safety of treatments for Alzheimer's disease. * To enable researchers to answer similar research questions and compare results in many different areas of the world. People with Alzheimer's disease who meet the eligibility criteria and agree to participate in the Study will be asked to visit their doctor (e.g. psychiatrist, geriatrician, or neurologist) at least once a year, or as frequently as is needed for their care. During or after their appointments they may be offered assessments, tests, medications, and treatments as determined by their doctor and their team. This is an observational data collection.

Follow from this

Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.

Stichting International Registry for Alzheimer's Disease and other Dementias FoundationNCT07213700Alzheimer's Disease(ad)Subjective Cognitive Decline (SCD)None, this is a non-interventional observational studyMild Cognitive Impairment (MCI)