Life sciences · Observational Study
ClinicalTrials.gov · September 28, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT07597512). This is a study registration, not published results. Lead sponsor: Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal. Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 223 participants (ESTIMATED). Conditions: Acute Heart Failure (AHF), Heart Failure, Congestion. Primary outcome measures: Residual Congestion at 72 Hours , 72 hours after admission.. Brief summary: The goal of this observational study is to learn how changes in urinary sodium and chloride levels relate to fluid overload and short-term outcomes in patients hospitalized with acute heart failure (AHF). The main questions it aims to answer are: * Do changes over time in urinary sodium and chloride reflect how well excess fluid is being removed during hospitalization? * Are these changes associated with residual congestion at discharge and with the risk of worsening heart failure or death after discharge? Participants hospitalized for AHF and treated with intravenous diuretics as part of their usual care will have clinical assessments, blood and urine tests, and echocardiographic evaluations collected at several time points during their hospital stay. Researchers will also record clinical outcomes, including worsening heart failure or death, at 30 days and 3 months after discharge.