Life sciences · Interventional Study
ClinicalTrials.gov · October 6, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07504120). This is a study registration, not published results. Lead sponsor: University of Illinois at Chicago. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 50 participants (ESTIMATED). Conditions: Multiple Sclerosis, Pilates Exercise, Walking, Balance, Fatigue in Multiple Sclerosis, Pain Management, Quality of Life, Depression, Cognition, Fatigue. Interventions: BEHAVIORAL: Pilates. Primary outcome measures: Change from baseline in walking endurance (Six-Minute Walk Test distance) , Baseline and 16 weeks (end of treatment); Change from baseline in walking speed (Timed 25-Foot Walk) , Baseline and 16 weeks (end of treatment); Change from baseline in balance (Berg Balance Scale) , Baseline and 16 weeks (end of treatment); Change from baseline in fatigue (Fatigue Severity Scale) , Baseline and 16 weeks (end of treatment); Change from baseline in pain (Short-form McGill Pain Questionnaire) , Baseline and 16 weeks (end of treatment). Brief summary: Objectives Objective 1: To determine the effects of a 16-week remotely delivered Pilates intervention on walking endurance, walking speed, balance, fatigue, and pain compared to a waitlist control group in individuals with MS. Objective 2: To examine the impact of a 16-week remotely delivered Pilates intervention on depression \& anxiety, cognitive function, and QOL compared to a waitlist control group in individuals with MS. Aim Aim 1: To assess whether the 16-week remotely delivered Pilates intervention significantly improves walking endurance, walking speed, balance, fatigue, and pain compared to a waitlist control group in individuals with MS Aim 2: To investigate whether the 16-week remotely delivered Pilates intervention significantly improves depression \& anxiety, cognitive function, and QOL compared to a waitlist control group in individuals with MS. Hypothesis Hypothesis 1: The 16-week remotely delivered Pilates intervention will significantly improve walking endurance, walking speed, balance, fatigue, and pain compared to a waitlist control group in individuals with MS. Hypothesis 2: Participants receiving the 16-week remotely delivered Pilates intervention will demonstrate significantly greater improvements in depression \& anxiety, cognitive function, and QOL compared to a waitlist control group in individuals with MS.