Life sciences · Preprint
arXiv · October 9, 2026
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Trajectory extrapolation from a partial target trajectory is underdetermined, but completed related trajectories provide information about the unresolved continuation. We propose target-constrained pooling (TCP), which separates the finite-horizon endpoint from continuation shape and estimates that endpoint from two complementary source signals. Uniform pooling captures final response levels, while matched-increment pooling captures the remaining change after aligning source and target states. TCP selects representative sources, projects both endpoint estimates onto a target-consistent region, converts them into corrections of the free forecast, and controls their influence through strength calibration and degradation-aware weighting. Across 25,245 targets from five domains and both forecasting directions, TCP reduces mean RMSE by 35.8% to 42.1% for all ten target-only forecasters and improves all 100 forecaster, dataset, and direction comparisons. The two endpoint signals consistently outperform either alone, while representative selection remains within 0.64% to 1.02% of the full donor pool using 12.7x fewer donor inputs and 138.8x fewer matching distance computations.