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Nanoparticles: Synthesis and Applications · Journal article
Future Journal of Pharmaceuticals and Health Sciences · August 27, 2026
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This is a narrative review that outlines the theoretical rationale for using nanotechnology-based antimicrobial agents to address antibiotic resistance. The source describes proposed mechanisms of action (reactive oxygen species production, DNA interference, membrane disruption, enzyme inhibition) and classes of nanomaterials (metallic, metal oxide, polymeric, lipid-based, carbon-based) without reporting experimental efficacy data, clinical trials, or head-to-head comparisons.
Journal article.
Nanoparticles possess unique physicochemical properties including high surface-to-volume ratio, higher reactivity, and improved contact with microbial membranes Multiple nanomaterial classes (metallic, metal oxide, polymeric, lipid-based, carbon-based) exhibit reported antibacterial activity against pathogenic microorganisms Proposed antimicrobial mechanisms include reactive oxygen species production, DNA replication interference, bacterial cell membrane disruption, and enzyme function impairment
No toxicity data, safety profile, or regulatory status of any nanotechnology-based antimicrobial agent provided
The source did not state who this applies to in practice.
This is a narrative review discussing the conceptual promise of nanotechnology-based antimicrobials against antibiotic resistance, with no primary experimental data, clinical outcomes, or comparative efficacy evidence presented.
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The successful treatment of infectious diseases is seriously threatened by antibiotic resistance, which has become a major worldwide health concern. The effectiveness of traditional antibiotics has decreased due to the rise in multidrug - resistant bacteria, which has made the creation of new treatment approaches necessary. Because of nanoparticles' unique physicochemical properties, such as a high surface - to - volume ratio, higher reactivity, and improved contact with microbial membranes, nanotechnology has em erged as a promising strategy for combating microbial resistance.Numerous nanomaterials, such as metallic, metal oxide, polymeric, lipid - based, and carbon - based nanomaterials, exhibit potent antibacterial activity against a range of pathogenic microorganisms.These nanoparticles produce reactive oxygen species, interfere with DNA replication, break bacterial cell membranes, and impede enzyme function, among other ways they have antimicrobial effects. Furthermore, the ecologically conscious and sustainable aspect of green nanoparticle synthesis with plant extracts has attracted interest. This study discusses nanoparticle kinds, methods of action, biological uses, toxicity considerations, and future research prospects in order to highlight the promise of nanotechnology - based antimicrobial agents as a novel approach to fight antibiotic resistance.
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