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Developmental Psychology · Observational Study
ClinicalTrials.gov · August 18, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a completed observational neuroimaging study registration examining associations between childhood temperament and brain function via fMRI in 550 children followed to age 29. No results are reported in this registry record; the document describes study design, enrollment, and planned outcome measures only.
Observational. Developmental Psychology; age from 2 Months; to 60 Years. Intervention: Non-Targets; Parents; Targets. n = 550. 1 site: United States.
This is a completed observational neuroimaging study registration examining associations between childhood temperament and brain function via fMRI in 550 children followed to age 29. No results are reported in this registry record; the document describes study design, enrollment, and planned outcome measures only.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
If results become available, this study may clarify neurobiological mechanisms linking childhood temperament to mood and anxiety disorder risk. Current registry record alone carries no clinical implications pending outcome publication.
This is a completed observational registry record with no reported results; it describes study design and enrollment only, making it a preliminary report of planned work rather than evidence of efficacy or outcome.
As stated by the source record.
Quoted from the source exactly as published.
If results become available, this study may clarify neurobiological mechanisms linking childhood temperament to mood and anxiety disorder risk. Current registry record alone carries no clinical implications pending outcome publication.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT00060775). This is a study registration, not published results. Lead sponsor: National Institute of Mental Health (NIMH). Recruitment status: COMPLETED. Study type: OBSERVATIONAL. Enrollment: 550 participants (ACTUAL). Conditions: Developmental Psychology. Primary outcome measures: Task performance , Up to 4 visits, though age 29; fMRI BOLD signal , Up to 4 visits, though age 29. Brief summary: The purpose of this study is to use brain imaging technology to examine brain changes that occur in children when they are exposed to various kinds of emotional tasks and to determine if these changes are related to the child's temperament. Studies suggest that the risk for developing mood and anxiety disorders in preschool children may be linked to differences in temperament. The relationship between temperament and risk or resilience may reflect the influences of brain activity on behavior at different stages of childhood development. Behavioral inhibition and mood or anxiety disorders have been linked to disturbances in the circuitry of several areas in the brain. However, the involvement of this circuitry in temperament remains unclear. This study will use functional magnetic resonance imaging (fMRI) to examine the function of different parts of the brain in children who have previously undergone temperament studies and have had their temperaments classified. Two sets of studies will be performed in the current protocol. A small set of pilot studies will be performed in infants, by staff at the University of Maryland. In terms of the studies among infants, these subjects will initially be contacted by staff at Maryland and then will be seen at the NIH for up to three visits lasting between 4- to 5- hours during the first year of life. These subjects also will undergo visits at the University of Maryland throughout the first year of life. This study will comprise up to four clinic visits. At Visit 1, children and their parents will meet with study staff individually and together for psychiatric interviews. Children will undergo a physical examination, medical history, a urine drug test, and practice in an fMRI simulator. Saliva samples will be collected from the children and tests will be given to assess stage of puberty, temperament, intelligence, feelings, experiences, and behavior. Other visits include fMRI scans of the brain and other tasks.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.