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Life sciences · Journal article
Orvosi Hetilap · November 1, 2026
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Most adult testicular tumors are germ cell tumors, among which teratoma may exhibit somatic-type malignant transformation. This phenomenon is uncommon (reported in approximately 3-8% of cases), may show carcinomatous or sarcomatous differentiation and is associated with an unfavorable prognosis and resistance to conventional therapies. We present the case of a 51-year-old man with metastatic testicular cancer. The tumor removed by semicastration was histologically identified as a rhabdomyosarcoma arising in a postpubertal teratoma. Due to the metastatic disease, cytotoxic treatment was initiated with VIP (etoposide-ifosfamide-cisplatin) regimen, followed by an EP (etoposide-cisplatin) protocol because of ifosfamide intolerance. Somatic-type malignant transformation of testicular teratoma is a rare entity that poses significant therapeutic challenges. The presence of a rhabdomyosarcoma component is associated with poor prognosis and often necessitates a sarcoma-oriented oncologic approach. Standard germ cell tumor chemotherapy protocols are generally of limited efficacy; therefore, a multidisciplinary approach, accurate histopathological diagnosis, and appropriate selection of therapy are essential. Orv Hetil. 2026; 167(44): 1790-1795.