Life sciences · Preprint
arXiv · October 6, 2026
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Retrieval-Augmented Generation (RAG) systems are vulnerable to prompt-injection attacks embedded in retrieved content. We introduce RAG-PIBench, a benchmark for RAG-style prompt-injection detection containing 4,876 contextual examples across frozen train, validation, and protected-test splits. Using a leakage-aware construction pipeline and strict evaluation protocol, we compare keyword-based, semantic-reference, TF-IDF, and transformer-based detectors. DistilBERT achieves the best protected-test performance (F1 = 0.896, PR-AUC = 0.968), while TF-IDF SVM and logistic regression remain competitive. Our results demonstrate the value of leakage-aware benchmark design and strong sparse baselines for reliable prompt-injection detection in RAG systems.