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Life sciences · Interventional Study
ClinicalTrials.gov · November 3, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07741773). This is a study registration, not published results. Lead sponsor: Augusta University. Recruitment status: NOT_YET_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 20 participants (ESTIMATED). Conditions: Mild Cognitive Impairment (MCI). Interventions: DIETARY_SUPPLEMENT: EVOO-phenolics dietary supplement; DIETARY_SUPPLEMENT: Placebo. Primary outcome measures: Cerebrovascular function , At baseline and end of treatment (6 months); Cerebrovascular blood flow , At baseline and end of treament (6 months); Cognitive function , At baseline and end of treament (6 months). Brief summary: The goal of this clinical trial is to determine whether the extra-virgin olive oil (EVOO) phenolic dietary supplement can improve memory function and modulate biomarkers among individuals with mild cognitive impairment (MCI). The main questions it aims to answer are: * Does dietary supplementation with EVOO phenolics improve cognitive function? * What would be the effect of the EVOO dietary supplement on other MCI-related biomarkers, including vascular function and biological pathways? Researchers will compare the EVOO dietary supplements with a placebo (a look-alike substance that contains no EVOO phenolics) Participants will: * Take EVOO dietary supplements or a placebo daily for 6 months * Visit the study site during the 6-month study for screening and testing.