Supervised exercise / Breast Cancer Early Stage Breast Cancer (stage 1 3) / Breast Neoplasm Malignant Female · Interventional Study

Supervised Exercise During Neoadjuvant Chemotherapy for Breast Cancer

ClinicalTrials.gov · August 13, 2026

Preliminary Why this matters to you Expert discussion

Early or partial results. Treat as a signal, not a conclusion.

AI Summary

This is a registered but not-yet-recruiting feasibility trial designed to assess whether supervised exercise can be safely delivered and completed during 4–6 months of neoadjuvant chemotherapy in women with early-stage breast cancer. No results are available; the study aims to answer whether the intervention is practical and safe, not to demonstrate efficacy, and will compare supervised aerobic and strength exercise to usual care.

What was studied

Interventional, Randomized, Parallel, Open label, Supportive Care purpose. Breast Cancer Early Stage Breast Cancer (Stage 1-3), Breast Neoplasm Malignant Female; Female; age from 18 Years. Intervention: Supervised exercise. Compared with: Control — No Intervention. n = 80. 1 site: Bahrain.

Key findings

Safety

Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.

Who this may help

This study is designed to establish feasibility and safety signals, not to demonstrate clinical benefit. Results, when available, will inform whether a larger efficacy trial on muscle mass, strength, quality of life, and chemotherapy tolerability is warranted.

Plain-language summary

This is a registry record for a planned feasibility study with no results posted; it describes a two-arm design assessing safety and feasibility of supervised exercise during neoadjuvant chemotherapy but enrollment has not yet begun.

Study design

As stated by the source record.

MethodsPrimary outcome measure: Feasibility of exercise intervention during neoadjuvant chemotherapy (assessed at From initiation of the supervised exercise program through completion of neoadj…)

DesignInterventional, Randomized, Parallel, Open label, Supportive Care purpose

PopulationBreast Cancer Early Stage Breast Cancer (Stage 1-3), Breast Neoplasm Malignant Female; Female; age from 18 Years

Sample size80

InterventionSupervised exercise

ComparatorControl — No Intervention

Setting1 site: Bahrain

Reported figures

Quoted from the source exactly as published.

Planned enrollment80

Primary outcome measureFeasibility of exercise intervention during neoadjuvant chemotherapy, assessed from initiation through completion of chemotherapy (approximately 4–6 months)

Study phaseNA

Clinical bottom line

Caveats

No results are posted in this registry record; study has not yet begun recruiting.
Primary outcome is feasibility, not efficacy or hard clinical endpoints.
Secondary outcomes (muscle mass, strength, quality of life, chemotherapy delivery) are named but not detailed.
Allocation concealment, blinding, and analytical approach not described in the registry record.

Evidence assessment

Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.

Study design

moderate

Interventional, two-arm comparison; feasibility primary outcome, not efficacy or clinical.

Directness

moderate

Addresses safety and feasibility in the target population during active chemotherapy treatment.

Consistency

insufficient

No results reported; consistency cannot be assessed from a registry record alone.

Risk of bias

insufficient

Study not yet recruiting; methods detail insufficient to assess blinding or allocation concealment.

Sample adequacy

limited

Estimated 80 participants for a feasibility study; small and not yet enrolled.

What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.

Source abstract

Registry record from ClinicalTrials.gov (NCT07764341). This is a study registration, not published results. Lead sponsor: King Hamad University Hospital, Bahrain. Recruitment status: NOT_YET_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 80 participants (ESTIMATED). Conditions: Breast Cancer Early Stage Breast Cancer (Stage 1-3), Breast Neoplasm Malignant Female. Interventions: OTHER: Supervised exercise. Primary outcome measures: Feasibility of exercise intervention during neoadjuvant chemotherapy , From initiation of the supervised exercise program through completion of neoadjuvant chemotherapy. The exercise program will continue throughout the full course of neoadjuvant chemotherapy, approximately 4-6 months depending on the treatment regimen.. Brief summary: The goal of this clinical trial is to learn whether supervised exercise is practical and safe for women receiving chemotherapy before surgery for breast cancer. The main questions it aims to answer are: * Can participants attend and complete the supervised exercise program during chemotherapy? * Is the exercise program safe? * Does exercise help maintain muscle mass, strength, quality of life, and chemotherapy delivery? Participants will be assigned to either: * supervised aerobic and strength exercise during chemotherapy, or * usual care without a study exercise program. Researchers will compare the two groups before and after chemotherapy.

Follow from this

Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.

King Hamad University Hospital, BahrainSupervised exerciseNCT07764341Breast Cancer Early Stage Breast Cancer (stage 1 3)Breast Neoplasm Malignant Female