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Life sciences · Observational Study
ClinicalTrials.gov · September 25, 2026
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Observational Study.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
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Registry record from ClinicalTrials.gov (NCT00531921). This is a study registration, not published results. Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID). Recruitment status: COMPLETED. Study type: OBSERVATIONAL. Enrollment: 313 participants (ACTUAL). Conditions: Heart Transplantation, Kidney Transplantation, Liver Transplantation, Lung Transplantation. Primary outcome measures: Association between proinflammatory mRNA expression in donor samples and subsequent development of early organ dysfunction in the immediate period following transplantation , Within first 7 days after transplant; Association of mRNA expression of proinflammatory mediatros in the transplanted organ in the immediate pre and post-reperfusion period with subsequent incidence of acute rejection and expression of genes involved in cell mediated immunity , 12 months after transplant. Brief summary: Activity of genes in donor tissues that are involved in inflammation are thought to be involved with early organ dysfunction, increased immune responses in transplant recipients, and organ rejection. The purpose of this study is to determine the relationship between genetic expression in donor and recipient tissue with transplant survival. Participants in this study will have received heart, lung, liver, or kidney transplants.