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Pelvic Floor Disorders Treatments / Colorectal Cancer Surgical Treatments · Journal article
Frontiers in Oncology · September 9, 2026
Early or partial results. Treat as a signal, not a conclusion.
This case report describes successful sphincter-preserving resection and functional recovery in one patient with KRAS-mutated ultra-low rectal cancer treated with bevacizumab plus XELIRI and electroacupuncture-based rehabilitation. The bowel function improved from over 30 stools per day to 7–10 stools at 6-month follow-up, but the evidence is anecdotal and does not support broad clinical recommendations without confirmatory studies.
Single-patient case report. A 55-year-old woman with KRAS-mutated ultra-low rectal adenocarcinoma, complicated by oxaliplatin allergy and insufficient tumor regression after multiple prior lines of chemotherapy, chemoradiotherapy, and immunotherapy.. Intervention: Bevacizumab plus XELIRI (five cycles) followed by laparoscopic radical rectal resection with transanal specimen extraction and Bacon-type pull-through reconstruction, and postoperative electroacupuncture rehabilitation at Baliao acupoints…. n = 1. Single center (not specified by name)..
Patient achieved R0 sphincter-preserving resection (ypT2N0, negative margins) after conversion therapy with bevacizumab plus XELIRI Bowel movement frequency decreased from over 30 times per day to approximately 10 times after resection, stabilizing at 7–10 times during 6-month follow-up Postoperative bowel function improvement documented using LARS score, MSKCC-BFI, and EORTC QLQ-C30 scales during four-week electroacupuncture rehabilitation
No report of adverse events or complications from conversion therapy or electroacupuncture.
This single case demonstrates feasibility of sphincter preservation in a difficult KRAS-mutated ultra-low rectal cancer with inadequate response to standard therapy, and suggests electroacupuncture may aid LARS recovery. However, the authors acknowledge that high-quality studies are required before this approach can be recommended for routine practice.
Single-case report of an individualized treatment strategy in ultra-low rectal cancer, documenting feasibility of sphincter preservation and bowel function recovery but lacking comparative data or generalizability.
As stated by the source record.
Quoted from the source exactly as published.
This single case demonstrates feasibility of sphincter preservation in a difficult KRAS-mutated ultra-low rectal cancer with inadequate response to standard therapy, and suggests electroacupuncture may aid LARS recovery. However, the authors acknowledge that high-quality studies are required before this approach can be recommended for routine practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Background KRAS-mutated ultra-low rectal cancer is associated with poor response to conventional neoadjuvant therapy, making sphincter preservation particularly challenging. In addition, effective rehabilitation strategies for severe low anterior resection syndrome (LARS) remain limited. Case presentation A 55-year-old woman with KRAS-mutated ultra-low rectal adenocarcinoma experienced insufficient tumor regression after multiple lines of chemotherapy, chemoradiotherapy, and immunotherapy, complicated by oxaliplatin allergy. After referral to our center, she received bevacizumab plus XELIRI combined with traditional Chinese medicine therapies. Following five treatment cycles, the patient underwent laparoscopic radical rectal resection with transanal specimen extraction and Bacon-type pull-through reconstruction. Pathological examination demonstrated negative proximal, distal, and circumferential margins, no metastatic involvement among 12 examined lymph nodes, and a final pathological stage of ypT2N0. The patient subsequently developed major LARS and underwent a four-week rehabilitation program centered on electroacupuncture at the Baliao acupoints. Assessment was conducted using the LARS score, Memorial Sloan Kettering Cancer Center Bowel Function Instrument (MSKCC-BFI), and EORTC QLQ-C30 scales. The patient’s bowel movement frequency decreased from over 30 times per day to approximately 10 times, and remained stable at 7–10 times during the 6-month follow-up. Conclusion In this patient, an individualized conversion strategy was followed by R0 sphincter-preserving resection, and postoperative bowel function improved temporally during and after multimodal rehabilitation that included electroacupuncture. This observation provide preliminary evidence in support of this treatment approach. However, high-quality studies are still required to comprehensively evaluate the efficacy of this treatment regimen.
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