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Cognitive Behavioral Therapy for Depression / Mood Monitoring / Depression · Interventional Study
ClinicalTrials.gov · September 4, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is an ongoing randomized trial comparing sequential versus single cognitive behavioral therapy for co-occurring insomnia and depression, with planned enrollment of 1200 participants and dual remission as the primary outcome at 3 months post-treatment. No results are reported in this registry record; the trial remains active and not yet recruiting.
Interventional, Randomized, Parallel, Single masking, Treatment purpose. Depression, Insomnia; age from 18 Years. Intervention: Single Insomnia Treatment; Single Depression Treatment; Sequenced Depression and Insomnia Treatment; Sequenced Insomnia and Depression Treatment. Compared with: Control — Active Comparator. n = 1,200. 1 site: United States.
This is an ongoing randomized trial comparing sequential versus single cognitive behavioral therapy for co-occurring insomnia and depression, with planned enrollment of 1200 participants and dual remission as the primary outcome at 3 months post-treatment. No results are reported in this registry record; the trial remains active and not yet recruiting.
This is a registry record only; no efficacy or safety results are reported
This trial will address whether sequential cognitive behavioral therapy for insomnia and depression is superior to single-condition treatment and whether individualized treatment matching improves outcomes. Results, once published, may inform clinical sequencing decisions and personalization strategies for patients with comorbid insomnia and depression.
This is a registry record for an active, ongoing trial with no results posted; it describes planned enrollment and primary endpoints only, without outcome data.
As stated by the source record.
Quoted from the source exactly as published.
This trial will address whether sequential cognitive behavioral therapy for insomnia and depression is superior to single-condition treatment and whether individualized treatment matching improves outcomes. Results, once published, may inform clinical sequencing decisions and personalization strategies for patients with comorbid insomnia and depression.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT05456607). This is a study registration, not published results. Lead sponsor: University of Rochester. Recruitment status: ACTIVE_NOT_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 1200 participants (ESTIMATED). Conditions: Depression, Insomnia. Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia; BEHAVIORAL: Cognitive Behavioral Therapy for Depression; BEHAVIORAL: Mood Monitoring. Primary outcome measures: Dual Remission of Depression and Insomnia , 3 Months post-treatment. Brief summary: This study has two primary objectives, each of which addresses critical clinical and research gaps for individuals who have co-occurring insomnia and depression. The first objective is to address whether sequential treatment of insomnia and depression is superior to a single treatment for either depression or for insomnia, and if so, which treatment sequence is optimal. The second objective is to determine if there are heterogeneity of treatment effects; that is, variation in which interventions are best for which individuals, and if so, to develop and individualized intervention rule to better match individuals with the treatment that is most likely to lead to the best outcomes. A large randomized trial will be conducted to meet these objectives.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.