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Life sciences · Journal article
Current Opinion in Pediatrics · October 20, 2026
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Purpose of review Resurgent outbreaks and declining childhood vaccination coverage have amplified the need for pediatricians to promptly recognize and manage vaccine-preventable diseases (VPDs). This review summarizes the epidemiology, clinical presentation, diagnostic evaluation, initial management, public health reporting, and prevention of selected VPDs relevant to pediatric practice. Recent findings Childhood vaccination coverage has declined in recent years, coinciding with renewed outbreaks and continued transmission of measles, mumps, pertussis, meningococcal disease, and hepatitis B in the United States. Recent federal immunization schedule changes for children and adolescents (e.g., revised hepatitis B birth-dose guidance, altered meningococcal vaccine decision-making, and expanded pentavalent meningococcal vaccine options) highlight the need for pediatricians to remain familiar with evolving vaccine recommendations. Summary Although routine immunization has dramatically reduced the burden of many VPDs, recent declines in vaccine coverage and notable outbreaks have renewed the need for clinical vigilance. Pediatricians should be prepared to identify characteristic presentations, implement appropriate isolation and infection-control measures, obtain timely diagnostic testing, initiate treatment or postexposure management when indicated, and reinforce vaccination as the cornerstone of prevention. This review provides a practical guide to the recognition and management of measles, mumps, pertussis, meningococcal disease, and hepatitis B in pediatric settings.