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Life sciences · Interventional Study
ClinicalTrials.gov · September 21, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07829510). This is a study registration, not published results. Lead sponsor: Medical University of South Carolina. Recruitment status: NOT_YET_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 300 participants (ESTIMATED). Conditions: Post-Traumatic Stress Disorder (PTSD), Depression, Substance Use Disorder, Traumatic Injury. Interventions: BEHAVIORAL: Trauma Resilience and Recovery Program Portal 2.0 (TRRP 2.0). Primary outcome measures: Posttraumatic Stress Symptom Severity as Measured by the PCL-8 , 3-month post-baseline; Number of Participants Screening Positive for Posttraumatic Stress Risk on the Injured Trauma Survivor Screen (ITSS) , Baseline; Change in Psychological Distress as Measured by the Kessler-6 (K6) , Baseline, 3-month postbaseline; Depressive Symptom Severity as Measured by the PHQ-8 , 3 months postbaseline; Frequency of Alcohol Use as Measured by the NIDA Quick Screen , 3 months postbaseline; General Life Satisfaction as Measured by PROMIS General Life Satisfaction , 3 months postbaseline; Frequency of Tobacco Use as Measured by the NIDA Quick Screen , 3 months postbaseline; Frequency of Prescription Drug Use for Nonmedical Reasons as Measured by the NIDA Quick Screen , 3 months postbaseline; Frequency of Illegal Drug Use as Measured by the NIDA Quick Screen , 3 months postbaseline; Number of Participants Screening Positive for Depression Risk on the Injured Trauma Survivor Screen (ITSS) , Baseline. Brief summary: This study evaluates the implementation and clinical effectiveness of the Trauma Resilience and Recovery Program (TRRP 2.0), a technology-enhanced behavioral health intervention designed for trauma center patients. TRRP 2.0 integrates screening, monitoring, and referral services for posttraumatic stress disorder (PTSD), depression, and substance use disorder (SUD). The study uses a two-phase design across two trauma centers: a usual care phase followed by implementation of TRRP 2.0. A total of 300 adult trauma patients will be recruited and followed for 3 months to assess behavioral health service utilization and clinical outcomes.