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Life sciences · Interventional Study
ClinicalTrials.gov · September 24, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07838519). This is a study registration, not published results. Lead sponsor: VA Office of Research and Development. Recruitment status: ENROLLING_BY_INVITATION. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 1400 participants (ESTIMATED). Conditions: Lung Cancer Screening, Military Service-related Environmental and Occupational Exposures, Cancer Survivor, Family History of Lung Cancer, COPD, Burn Pit Exposure, Agent Orange Exposure, Radiation Exposure, Asbestos Exposure, Lung Neoplasm. Interventions: PROCEDURE: Low-dose computed tomography. Primary outcome measures: Lung cancer incidence , 3-44 months from time of study enrollment. Brief summary: Lung cancer screening with low-dose chest computed tomography (CT) is currently recommended for high-risk individuals who are 50 to 80 years old, have smoked cigarettes for at least 20 pack-years, and currently smoke or quit smoking within the past 15 years. In a prospective cohort at Nashville, Denver, Louisville, Chicago, Kansas City, Salisbury and Seattle Veteran Affairs medical centers, the investigators will evaluate the detection of lung cancer using an expanded screening eligibility criteria based on Veterans' personal and service-related exposures compared to standard of care criteria. Screening a larger population will increase the number of lung nodules needing clinical management and these nodules may or may not be cancer. In a population of Veterans with positive screenings at Nashville, the investigators will also validate a combination biomarker-based approach to manage screen-detected lung nodules to reduce time to lung cancer diagnosis and use of invasive procedures. This study will also convene a Veteran Community Advisory Board and interview Veterans to better understand their thoughts about lung cancer screening and preferences for outreach and engagement.