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Life sciences · Preprint
arXiv · September 24, 2026
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Learning surrogates for time-dependent partial differential equations often requires a new simulation corpus when the governing operator changes. We introduce RD-JEPA, a joint-embedding predictive architecture for self-supervised pretraining on reaction-diffusion trajectories. A single model is pretrained on five parameterized systems and then adapted to three held-out systems whose reaction operators and trajectories are excluded from pretraining. Using one, five, or ten complete trajectories from a held-out system, RD-JEPA achieves lower mean relative discrete $\ell^2$ field error and mean absolute spatial first-difference error than five supervised surrogate baselines, an independently trained control that removes the trajectory-dependent predictive latent pathway, and an architecture-matched model trained from scratch. Within the evaluated equations, output resolution, forecast horizons, and choices of adaptation trajectories, the results indicate that prediction of future-state representations can support data-efficient adaptation across related reaction-diffusion systems.