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Transcranial Magnetic Stimulation / Vagus Nerve Stimulation / Depression · Interventional Study
ClinicalTrials.gov · August 12, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a recruitment-phase registry record for a small within-subject crossover trial comparing transcutaneous auricular vagus nerve stimulation (taVNS), transcranial magnetic stimulation (TMS), and their combination in 24 participants with depression. No results are posted; the trial is designed to assess feasibility and effect on Hamilton Depression Rating Scale and PHQ-9 over approximately 8 weeks of treatment.
Interventional, Randomized, Crossover, Triple masking, Treatment purpose. Depression; age from 18 Years; to 75 Years. Intervention: Vagus Nerve Stimulation (VNS) only; Transcranial Magnetic Stimulation (TMS) only; Synchronized VNS and TMS. Compared with: Within-subject crossover: each participant receives all three conditions (VNS/taVNS alone, TMS alone, both combined) in randomized order.. n = 24. 1 site: United States.
This is a recruitment-phase registry record for a small within-subject crossover trial comparing transcutaneous auricular vagus nerve stimulation (taVNS), transcranial magnetic stimulation (TMS), and their combination in 24 participants with depression. No results are posted; the trial is designed to assess feasibility and effect on Hamilton Depression Rating Scale and PHQ-9 over approximately 8 weeks of treatment.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
No clinical impact can be derived from a registry record with no results. Clinicians should await completion and peer-reviewed publication of this trial before considering its findings for practice.
Registry record of a small, recruiting interventional study with no reported results; the planned design is reasonable but the evidence base is not yet established.
As stated by the source record.
Quoted from the source exactly as published.
No clinical impact can be derived from a registry record with no results. Clinicians should await completion and peer-reviewed publication of this trial before considering its findings for practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT05725239). This is a study registration, not published results. Lead sponsor: Medical University of South Carolina. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 24 participants (ESTIMATED). Conditions: Depression. Interventions: DEVICE: Vagus Nerve Stimulation; DEVICE: Transcranial Magnetic Stimulation. Primary outcome measures: Change in Hamilton Depression Rating Scale , Through study completion, an average of 8 weeks; Change in Patient Health Questionnaire 9 , Through study completion, an average of 8 weeks. Brief summary: The purpose of the research is to test out a combined treatment for depression where the investigators stimulate a nerve in the ear while at the same time stimulate the brain with magnets. These treatments are called transcutaneous (through the skin) auricular (ear) vagus nerve stimulation (taVNS) and transcranial (through the skull) magnetic stimulation (TMS). For participants who already have a cervical VNS device, the investigators will not change their treatment and will use this in place of the taVNS. The investigators think this combined method might treat depressive symptoms better than either alone. This study is in person at the Institute of Psychiatry in downtown Charleston on the MUSC campus. First, participants will have a screening session and then will have 6 treatment days total where participants will receive either VNS treatment alone, TMS treatment alone, or both at the same time. The treatment that participants start with will be randomized, and they will have 2 treatment days of each combination.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.